CALL FOR PAPERS Cardiovascular Consequences of Obesity and Type 2 Diabetes Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese Zucker rats
نویسندگان
چکیده
Jefferson C. Frisbee, Adam G. Goodwill, Stephanie J. Frisbee, Joshua T. Butcher, Robert W. Brock, I. Mark Olfert, Evan R. DeVallance, and Paul D. Chantler Department of Physiology and Pharmacology, West Virginia University Health Sciences Center, Morgantown, West Virginia; Department of Health Policy, Management and Leadership, West Virginia University Health Sciences Center, Morgantown, West Virginia; Division of Exercise Physiology, West Virginia University Health Sciences Center, Morgantown, West Virginia; and Center for Cardiovascular and Respiratory Sciences, West Virginia University Health Sciences Center, Morgantown, West Virginia
منابع مشابه
Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese Zucker rats.
Evolution of metabolic syndrome is associated with a progressive reduction in skeletal muscle microvessel density, known as rarefaction. Although contributing to impairments to mass transport and exchange, the temporal development of rarefaction and the contributing mechanisms that lead to microvessel loss are both unclear and critical areas for investigation. Although previous work suggests th...
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Background. We investigated the effects of exercise training (ET) on miR-126 levels and skeletal muscle angiogenesis in obese Zucker rats. Results. Zucker rats were randomly assigned to sedentary and swimming-trained groups: lean sedentary (LS) and trained (LTR); obese sedentary (OB) and trained (OBTR). The OB group displayed capillary rarefaction compared with the LS group. In contrast, ET inc...
متن کاملExercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats.
The purpose of this study was to test the hypothesis that exercise training improves microvascular function in obese Zucker rats, a model of obesity and type II diabetes. Animals were divided into four age-matched groups: lean sedentary (LS), lean exercise (LE), obese sedentary (OS), and obese exercise (OE). The exercise groups were treadmill-exercised from 5 to 11 wk of age, including a 2-wk a...
متن کاملChanges in Mitochondrial Dynamic Factors (mfn2 and drp1) Following High Intensity Interval Training and Moderate Intensity Continuous Training in Obese Male Rats
Objective: Mitochondrial content and function are important determinants of oxidative capacity and metabolic efficiency of skeletal muscle tissue. The aim of this study was to investigate the changes in mitochondrial dynamic factors (mfn2 and drp1) following high intensity interval training (HIIT) and moderate intensity continuous training (MICT) in obese male rats. Materials and Methods: In t...
متن کاملRemodeling of the skeletal muscle microcirculation increases resistance to perfusion in obese Zucker rats.
Whereas previous studies have demonstrated that the development of syndrome X in obese Zucker rats (OZR) is associated with impaired arteriolar reactivity to vasoactive stimuli, additional results from these studies indicate that the passive diameter of skeletal muscle arterioles is reduced in OZR versus lean Zucker rats (LZR). On the basis of these prior observations, the present study evaluat...
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